Sodium borohydride → HCID 54195003, compound

Participants

Reaction Steps

85 g (0.27 mole) of 4,4-dimethyl-1-(naphth-2-yl)-2-(1,2,4-triazol-1-yl)-1-penten-3-one (Example 1) were taken up in 200 ml of methanol, and 6 g of sodium borohydride were added in portions, while stirring and cooling. When the reaction had ended, the reaction mixture was adjusted to pH 6 and concentrated. The residue was taken up in methylene chloride, washed with saturated sodium bicarbonate solution, dried over sodium sulphate, filtered and concentrated. The oily residue was made to crystallized by adding ether. 41 g (49% of theory) of 4,4-dimethyl-1-(naphth-2-yl)-2-(1,2,4-triazol-1-yl)-1-penten-3-ol of melting point 122°-124° C. were obtained.

Provenance & Evidence