Methyl iodide → HCID 178503166, compound

Participants

Reaction Steps

To a stirred solution of 3-t-butylpyrazole-5-thione (2.0 g) in glyme (50 ml) was added sodium hydride (0.6 g) in small quantities, with cooling. After stirring the mixture briefly at room temperature, iodomethane (1.85 g, 0.9 ml) was added. The reaction mixture was stirred at room temperature, then the solvent evaporated in vacuo. The residue was extracted with ether and washed with water to give after evaporation, 3-t-butyl-5-(methylthio)pyrazole (0.8 g, 36% yield), of melting point 135°-6° (after recrystallisation from petrol). The product was identical, by nuclear magnetic resonance spectroscopy, to that of Example 2.

Provenance & Evidence