反应详情

To an ice-cold suspension of 3-hydrazino-4-carboxy-6-chloro-pyridazine (1.88 g; 0.01 mole) in 15% acetic acid, a solution of sodium nitrite (0.70 g) in water (5 ml) was added dropwise. After stirring for one hour at 5°-10° C. the separated precipitate was filtered, washed with anhydrous ethanol. The solid was suspended in 2 N HCl, the mixture was stirred for 30 minutes, the solid was stirred off, washed with cold water and dried under vacuum at 70° C. to give 1.73 g (87%) of the title compound, m.p. 225° C.

1. filtrationwas filtered
2. washwashed with anhydrous ethanol
3. stirringthe mixture was stirred for 30 minutes
4. stirringthe solid was stirred off
5. washwashed with cold water
6. customdried under vacuum at 70° C.