Hydrochloric Acid → HCID 131712725, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 3-acetoxymethyl-7-[2-(2-amino-4-thiazolyl)-2-methoxyiminoacetamido]-3-cephem-4-carboxylic acid (syn-isomer) (0.456 g, 0.001 mole) and NaHCO3 (0.143 g, 0.0017 mole) in water (10 ml), 8-carboxy-6-mercapto-tetrazolo[1,5-b]pyridazine (0.138 g, 0.0007 mole) was added. A slow stream of nitrogen was passed through the solution, and the mixture was heated at 50° C. for 12 hours, while keeping the pH at 6.8. After cooling, the solution was acidified with 10% HCl, the precipitate collected by filtration, washed with water and then with ethanol. There was thus obtained 0.245 g of the title compound which was shown by N.M.R., T.L.C. and I.R. to be identical to the product described in Example 4, apart a minor contaminant of the anti-isomer.

Provenance & Evidence