HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 2-(2-Aminothiazol-4-yl)-2-pentyloxyiminoacetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 2-(2-aminothiazol-4-yl)-2-pentyloxyiminoacetate | HCID 54426052 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-(2-Aminothiazol-4-yl)-2-pentyloxyiminoacetic acid | HCID 54540176 | 86.9% |
Reaction Steps
Ethyl 2-pentyloxyimino-2-(2-amino-1,3-thiazol-4-yl)acetate (syn isomer) (28.6 g.) and 2 N sodium hydroxide aqueous solution (100.2 ml.) were reacted in a mixture of methanol (100 ml.) and tetrahydrofuran (100 ml.) according to similar manners to those of Preparation (9-1) and (9-2) to give 2-pentyloxyimino-2-(2-amino-1,3-thiazol-4-yl)acetic acid (syn isomer) (22.4 g.), mp 176° C. (dec.)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04331664 |
| Source dataset | uspto-grants-1982_05 |
| ORD ID | ord-5bb9780d3eb74cb791feda054bed4ac2 |
| Source note | uspto-grants-1982_05 |