Hydrochloric Acid → HCID 131712736, compound

Participants

Reaction Steps

7-[2-Propoxyimino-2-(2-formamido-1,3-thiazol-4-yl)acetamido]-3-carbamoyloxymethyl-3-cephem-4-carboxylic acid (syn isomer)(0.5 g) was suspended in methanol (15 ml). To the suspension was added conc. hydrochloric acid (0.2 ml) and the mixture was stirred for 2 hours at ambient temperature. The reaction mixture was concentrated and the residue was washed with tetrahydrofuran, collected by filtration and dried to give 7-[2-propoxyimino-2-(2-amino-1,3-thiazol-4-yl)acetamido]-3-carbamoyloxymethyl-3-cephem-4-carboxylic acid hydrochloride (syn isomer)(0.4 g).

Provenance & Evidence