(R)-(+)-1-Phenylpropyl isocyanate → 4(S)-tert-butyl-2-oxoazetidine-1-carboxylic acid (1(R)-phenylpropyl)amide

HRID 1066022Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1066022
[C:1]([C@H:5]1[NH:8][C:7](=[O:9])[CH2:6]1)([CH3:4])([CH3:3])[CH3:2].[C:10]1([C@H:16]([N:19]=[C:20]=[O:21])[CH2:17][CH3:18])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>>[C:10]1([C@H:16]([NH:19][C:20]([N:8]2[C@H:5]([C:1]([CH3:4])([CH3:3])[CH3:2])[CH2:6][C:7]2=[O:9])=[O:21])[CH2:17][CH3:18])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

Komponenten

3

Edukt 2

HCID 7018288(R)-(+)-1-Phenylpropyl isocyanateHCID 206598394(S)-tert-butylazetidine-2-one

Produkt 1

HCID 543353084(S)-tert-butyl-2-oxoazetidine-1-carboxylic acid (1(R)-phenylpropyl)amide

Versuchsvorschrift

Following the same procedure as in example 1, step F, but using 4(S)-tert-butylazetidine-2-one as starting material and 1(R)-phenylpropyl isocyanate as reactant, 4(S)-tert-butyl-2-oxoazetidine-1-carboxylic acid (1(R)-phenylpropyl)amide was obtained as a waxy solid.

Quellen und Nachweise

ORD-Eintrag
ord-bf230b4e366549e49cd6131beedaea89
Quelldatensatz
uspto-grants-2001_06
Patentnummer
US06242439B1

Notizen zur Reaktion

Wird geladen…