Chlorosulfonic acid → HCID 135515526, compound

Participants

Reaction Conditions

Reaction Steps

Compound 5a (0.95 g, 0.003 mole) was added in portions to chlorosulfonic acid (2 ml) cooled to 0° C. (ice-bath) under stirring. The resulting yellow solution was then allowed to attain room temperature and was subsequently slowly heated to 65-70° C. (oil bath) for 1 h. The reaction mixture was then slowly poured onto crushed ice (25 g), whereby a white solid precipitated immediately. The white solid was filtered, dried and recrystallized from THF/petroleum ether (b.p. 40-60° C.), thereby yielding 6a.

Provenance & Evidence