反应详情

Bromine (0.6 mol) is added to a mixture of 1,3-dichloro-5-fluorobenzene (0.6 mol) and ferrous powder within 2 hours. The brown reaction mixture is stirred 16 hours at room temperature and subsequently washed with dichloromethane and water. The organic layer is separated, washed with sodium hydrogen carbonate solution and dried with anhydrous sodium sulphate. The solvent is evaporated under reduced pressure. The raw product is recrystallized in ethanol to yield 61 g of the product as a white powder having a melting point of 83° C.

1. washsubsequently washed with dichloromethane and water
2. customThe organic layer is separated
3. washwashed with sodium hydrogen carbonate solution
4. dry with materialdried with anhydrous sodium sulphate
5. customThe solvent is evaporated under reduced pressure
6. customThe raw product is recrystallized in ethanol