Potassium Iodide → HCID 9911815, compound

Participants

Reaction Steps

A mixture containing 4-piperazinoindole (0.2 mmole), potassium carbonate (0.5 mmole), potassium iodide (0.08 mmole) and 4-benzyl-5-chloromethyl-2-cyclohexyl oxazole (0.19 mmole) from example 2 was stirred in acetone (2 ml) for 16 hr. The mixture was concentrated in vacuo, water (10 ml) added, and the product extracted into dichloromethane (2×10 ml). The combined organics was washed with water (5 ml), dried over anhydrous magnesium sulfate, filtered and concentrated in vacuo to afford the required product as a beige solid (94% yield). An ethanolic solution (5 ml) of the product was treated with fumaric acid (1 equivalent), and the resulting salt crystallized from diethyl ether to afford the titled product as a light beige powder.

Provenance & Evidence