1-(2-Methoxyphenyl)piperazine → HCID 10181699, compound

Participants

Reaction Steps

A suspension containing 2-methoxyphenylpiperazine (1.0 mmole), potassium carbonate (2.0 mmole), potassium iodide (0.5 mmole) and 4-benzyl-5-chloromethyl-2-phenyloxazole (1.0 mmole) from example 6, was stirred in acetone (15 ml) at ambient temperature for 16 hr. The solvent was removed in vacuo, water (50 ml) added and the product extracted into ethyl acetate (2×50 ml). The combined organics were washed with water (40 ml), brine (40 ml), dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. The product was purified by “flash” chromatography over silica gel to afford the titled compound as an off-white crystalline powder (0.74 mmole, 74% yield). This was transformed into its mono-fumarate salt, an off-white crystalline powder, using the procedure outlined in example 10 above. mp 175-175° C.

Provenance & Evidence