Potassium Iodide → HCID 21197966, compound

Participants

Reaction Steps

A suspension containing 2-fluorophenylpiperazine (2.0 mmole), potassium carbonate (4.0 mmole), potassium iodide (1.0 mmole) and 4-benzyl-5-chloromethyl-2-cyclohexylmethyl oxazole (2.0 mmole) from example 8, was stirred in acetone (20 ml) at ambient temperature for 18 hr. The solvent was removed in vacuo, water (50 ml) added and the product extracted into ethyl acetate (3×50 ml). The combined organics were washed with water (50 ml), dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. The product was purified by “flash” chromatography over silica gel to afford the titled compound as an off-white crystalline powder (1.3 mmole, 65% yield). An ethyl acetate solution (10 ml) of the product was treated with 2 equivalents of ethereal 1N-HC1 to afford the HCl salt of the titled compound as a white solid.

Provenance & Evidence