3-Chloropropyl 2,4-dimethylphenyl ether → 1-(3-(2,4-Dimethylphenoxy)prop-1-yl)-4-hydroxy-4-(quinolin-3-yl)piperidine

HRID 1066081ノート

反応式

HRID 1066081 の反応式
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[O:9][CH2:10][CH2:11][CH2:12]Cl.[OH:14][C:15]1([C:21]2[CH:22]=[N:23][C:24]3[C:29]([CH:30]=2)=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1>>[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[O:9][CH2:10][CH2:11][CH2:12][N:18]1[CH2:19][CH2:20][C:15]([OH:14])([C:21]2[CH:22]=[N:23][C:24]3[C:29]([CH:30]=2)=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH2:16][CH2:17]1

参加物

3

反応物 2

HCID 167924883-Chloropropyl 2,4-dimethylphenyl etherHCID 211980104-(Quinolin-3-yl)piperidin-4-ol

生成物 1

HCID 98652121-(3-(2,4-Dimethylphenoxy)prop-1-yl)-4-hydroxy-4-(quinolin-3-yl)piperidine収率 45%

実験手順

Beginning with 0.235 gm (1.2 mMol) 3-chloropropyl 2,4-dimethylphenyl ether and 0.270 gm (1.2 mMol) 4-hydroxy-4-(quinolin-3-yl)piperidine, 0.209 gm (45%) of the title compound were recovered as a white solid.

出典と根拠

ORDレコード
ord-7425b03a385647d6a611fb5adfb5d325
出典データセット
uspto-grants-2001_06
特許番号
US06242450B1

反応ノート

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