4-(Quinolin-3-yl)piperidin-4-ol → HCID 9824137, compound

HRID 1066085Notes

Reaction equation

HRID 1066085 reaction equation
[CH3:1][C:2]1([CH3:16])[CH2:6][C:5]2[CH:7]=[CH:8][CH:9]=[C:10]([O:11][CH2:12][CH2:13][CH2:14]Cl)[C:4]=2[O:3]1.[OH:17][C:18]1([C:24]2[CH:25]=[N:26][C:27]3[C:32]([CH:33]=2)=[CH:31][CH:30]=[CH:29][CH:28]=3)[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1>>[CH3:1][C:2]1([CH3:16])[CH2:6][C:5]2[CH:7]=[CH:8][CH:9]=[C:10]([O:11][CH2:12][CH2:13][CH2:14][N:21]3[CH2:22][CH2:23][C:18]([OH:17])([C:24]4[CH:25]=[N:26][C:27]5[C:32]([CH:33]=4)=[CH:31][CH:30]=[CH:29][CH:28]=5)[CH2:19][CH2:20]3)[C:4]=2[O:3]1

Participants

3

Reactant 2

HCID 211980104-(Quinolin-3-yl)piperidin-4-olHCID 21198081HCID 21198081, compound

Product 1

HCID 9824137HCID 9824137, compoundYield 46.6%

Procedure

Beginning with 0.316 gm (1.3 mMol) 3-chloropropyl 2,2-dimethyl-2,3-dihydrobenzofur-7-yl ether and 0.300 gm (1.3 mMol) 4-hydroxy-4-(quinolin-3-yl)piperidine, 0.262 gm (46%) of the title compound were recovered as a white solid.

Sources & evidence

ORD record
ord-f5727a84f4d241c8bef088128a9c2734
Source dataset
uspto-grants-2001_06
Patent number
US06242450B1

Reaction notes

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