4-(3-chloropropoxy)-1H-indole → 1-(3-(Indol-4-yloxy)prop-1-yl)-4-(quinolin-3-yl)piperidine

HRID 1066086Notes

Reaction equation

HRID 1066086 reaction equation
[NH:1]1[C:9]2[C:4](=[C:5]([O:10][CH2:11][CH2:12][CH2:13]Cl)[CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.[N:15]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH:18]=[C:17]([CH:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)[CH:16]=1>>[NH:1]1[C:9]2[C:4](=[C:5]([O:10][CH2:11][CH2:12][CH2:13][N:28]3[CH2:29][CH2:30][CH:25]([C:17]4[CH:16]=[N:15][C:24]5[C:19]([CH:18]=4)=[CH:20][CH:21]=[CH:22][CH:23]=5)[CH2:26][CH2:27]3)[CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1

Participants

3

Reactant 2

HCID 116941694-(3-chloropropoxy)-1H-indoleHCID 190962263-(Piperidin-4-yl)quinoline

Product 1

HCID 98431171-(3-(Indol-4-yloxy)prop-1-yl)-4-(quinolin-3-yl)piperidineYield 68%

Procedure

Beginning with 0.175 gm (0.83 mMol) 3-chloropropyl indol-4-yl ether and 0.177 gm (0.83 mMol) 4-(quinolin-3-yl)piperidine, 0.217 gm (68%) of the title compound were recovered as an off-white solid.

Sources & evidence

ORD record
ord-ae88bbf37a724dfc99ef28df3da234c9
Source dataset
uspto-grants-2001_06
Patent number
US06242450B1

Reaction notes

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