Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Chloride | HCID 312 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Isopropyl Isothiocyanate | HCID 75263 | — |
| Reactant | 2-Amino-4,6-dichlorobenzene-1-sulfonamide | HCID 3021430 | — |
| Catalyst | Copper | HCID 23978 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 178456985 | HCID 178456985 | — |
Reaction Steps
A mixture of 2-amino-4,6-dichlorobenzenesulfonamide (1.0 g), isopropyl isothiocyanate (0.84 g), copper(l) chloride (0.4 g), and DMF (1.5 ml) was heated at 100° C. for 2 h. Then 5 ml of methanol was added and the precipitated material was removed by filtration. Evaporation of the solvent in vacuo and subsequent treatment of the residue with 25 ml of ethyl acetate gave a yellow precipitate, which was collected by filtration and recrystallized from ethanol to give the title compound as white crystals; m.p. 291-293° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06242443B1 |
|---|
| Source dataset | uspto-grants-2001_06 |
|---|
| ORD ID | ord-cdd47aca00774ef0a7b94284b734a86b |
|---|
| Source note | uspto-grants-2001_06 |
|---|
