Phosgene → HCID 178456981, compound

HRID 1066092Notes

Reaction equation

HRID 1066092 reaction equation
NC1C=C(S(C2C=CC=CC=2)(=O)=O)C=CC=1S(N)(=O)=O.C(N=C=S)(C)C.[NH2:27][C:28]1[CH:33]=[C:32]([S:34]([C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)(=[O:36])=[O:35])[CH:31]=[CH:30][C:29]=1[S:43]([NH:46][C:47]([NH:49][CH:50]([CH3:52])[CH3:51])=S)(=[O:45])=[O:44].C(Cl)(Cl)=O>>[CH:50]([NH:49][C:47]1[NH:27][C:28]2[CH:33]=[C:32]([S:34]([C:37]3[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=3)(=[O:35])=[O:36])[CH:31]=[CH:30][C:29]=2[S:43](=[O:44])(=[O:45])[N:46]=1)([CH3:52])[CH3:51]

Participants

5

Reactant 4

HCID 6371PhosgeneHCID 75263Isopropyl IsothiocyanateHCID 1524682-Amino-4-phenylsulfonylbenzenesulfonamideHCID 21197926HCID 21197926, compound

Product 1

HCID 178456981HCID 178456981, compound

Procedure

Starting from 2-amino-4-(benzenesulfonyl)benzenesulfonamide and isopropyl isothiocyanate, and following a procedure analogous to the one described in Example 4a, N-(2-amino-4-(benzenesulfonyl)benzenesulfonyl)-N′-isopropylthiourea was prepared; m.p. 178-180° C. Subsequent ring closure with phosgene by a procedure analogous to the one described in Example 4b gave the title compound, m.p. 308-310° C.

Workup

  1. customwas prepared

Sources & evidence

ORD record
ord-f487c6c6f51d460f8c58daa97bd08d67
Source dataset
uspto-grants-2001_06
Patent number
US06242443B1

Reaction notes

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