Phosgene → HCID 178421836, compound

Participants

Reaction Steps

Starting from 2-amino-4-chloro-5-methylbenzenesulfonamide and isopropyl isothiocyanate, and following a procedure analogous to the one described in Example 4a, N-(2-amino-4-chloro-5-methylbenzenesulfonyl)-N′-isopropylthiourea was prepared; m.p. 120-122° C. Subsequent ring closure with phosgene by a procedure analogous to the one described in Example 4b gave the title compound; 1H-NMR (d6-DMSO), δ (ppm): 10.3 (br, 1H, NH), 7.68 (1H, arom.), 7.29 (1H, arom), 7.2 (br, 1H, NH), 4.0-3.8 (m, 1H, CH), 2.37 (s, 3H, CH3), 1.20 (d, 6H, CH3).

Provenance & Evidence