Phosgene → HCID 178456984, compound

HRID 1066096Notes

Reaction equation

HRID 1066096 reaction equation
NC1C=CC=C(Cl)C=1S(N)(=O)=O.C(N=C=S)(C)C.[NH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([Cl:26])[C:21]=1[S:27]([NH:30][C:31]([NH:33][CH:34]([CH3:36])[CH3:35])=S)(=[O:29])=[O:28].C(Cl)(Cl)=O>>[Cl:26][C:22]1[C:21]2[S:27](=[O:29])(=[O:28])[N:30]=[C:31]([NH:33][CH:34]([CH3:36])[CH3:35])[NH:19][C:20]=2[CH:25]=[CH:24][CH:23]=1

Participants

5

Reactant 4

HCID 6371PhosgeneHCID 75263Isopropyl IsothiocyanateHCID 2119781589639-40-7HCID 21197819HCID 21197819, compound

Product 1

HCID 178456984HCID 178456984, compound

Procedure

Starting from 2-amino-6-chlorobenzenesulfonamide and isopropyl isothiocyanate, and following a procedure analogous to the one described in Example 4a, N-(2-amino-6-chlorobenzenesulfonyl)-N′-isopropylthiourea was prepared; m.p. 144-146° C. Subsequent ring closure with phosgene by a procedure analogous to the one described in Example 4b gave the title compound; m.p. 273-275° C.

Workup

  1. customwas prepared

Sources & evidence

ORD record
ord-8b9c97e7b4504c0991f7ae7e5368396d
Source dataset
uspto-grants-2001_06
Patent number
US06242443B1

Reaction notes

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