Isopropyl Isothiocyanate → HCID 178456960, compound

Participants

Reaction Steps

Starting from 2-amino-4-isopropylbenzenesulfonamide and isopropyl isothiocyanate, and following a procedure analogous to the one described in Example 4a, N-(2-amino-4-isopropylbenzenesulfonyl)-N′-isopropylthiourea was prepared. The crude product containing approx. 16% starting material (by 1H-nmr) was used without purification for the next step. Subsequent ring closure with phosgene by a procedure analogous to the one described in Example 4b gave the title compound; m.p. 237-239° C.

Provenance & Evidence