Phosgene → HCID 178456958, compound

HRID 1066101Notes

Reaction equation

HRID 1066101 reaction equation
NC1C=C(C2CCCCC2)C=CC=1S(N)(=O)=O.C(N=C=S)(C)C.[NH2:24][C:25]1[CH:30]=[C:29]([CH:31]2[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]2)[CH:28]=[CH:27][C:26]=1[S:37]([NH:40][C:41]([NH:43][CH:44]([CH3:46])[CH3:45])=S)(=[O:39])=[O:38].C(Cl)(Cl)=O>>[CH:31]1([C:29]2[CH:28]=[CH:27][C:26]3[S:37](=[O:39])(=[O:38])[N:40]=[C:41]([NH:43][CH:44]([CH3:46])[CH3:45])[NH:24][C:25]=3[CH:30]=2)[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]1

Participants

5

Reactant 4

HCID 6371PhosgeneHCID 75263Isopropyl IsothiocyanateHCID 21197841HCID 21197841, compoundHCID 21197880HCID 21197880, compound

Product 1

HCID 178456958HCID 178456958, compound

Procedure

Starting from 2-amino-4-cyclohexylbenzenesulfonamide and isopropyl isothiocyanate, and following a procedure analogous to the one described in Example 4a, N-(2-amino-4-cyclohexylbenzenesulfonyl)-N′-isopropylthiourea was prepared; m.p. 131-133° C. Subsequent ring closure with phosgene by a procedure analogous to the one described in Example 4b gave the title compound; m.p. 264-266° C.

Workup

  1. customwas prepared

Sources & evidence

ORD record
ord-064d5bdef186471781539db8ece2485f
Source dataset
uspto-grants-2001_06
Patent number
US06242443B1

Reaction notes

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