Hydrogen Bromide → HCID 178456957, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 3-isopropylamino-6-trifluoromethyl-4H-1,2,4-benzothiadiazine 1,1-dioxide (307 mg; 1 mmol) in water (5 ml) was added 40% hydrobromic acid (0.44 ml; 3 mmol). The solution was then heated to 70° C. and 30% hydrogen peroxide (0.33 g; 3 mmol) was added. After 30 min the reaction mixture was cooled and extracted with ethyl acetate (20 ml) and purified by column chromatograpy (ethyl acetate:ethanol 9:1). Concentration of the appropiate fractions produced the title compound (22 mg); 1H-NMR (DMSO-d6) ppm; 7.60 (s, 1H), 7.10 (s, 1H), 6.65 (s, 1H), 3.95 (m, 1H) 1.11 (d, 6H).

Provenance & Evidence