2-Butanamine, 3,3-dimethyl- → HCID 178463651, compound

HRID 1066113Notes

Reaction equation

HRID 1066113 reaction equation
Cl[C:2]1[NH:7][C:6]2[CH:8]=[C:9]([Cl:12])[CH:10]=[CH:11][C:5]=2[S:4](=[O:14])(=[O:13])[N:3]=1.[CH3:15][CH:16]([NH2:21])[C:17]([CH3:20])([CH3:19])[CH3:18]>>[Cl:12][C:9]1[CH:10]=[CH:11][C:5]2[S:4](=[O:14])(=[O:13])[N:3]=[C:2]([NH:21][CH:16]([CH3:15])[C:17]([CH3:20])([CH3:19])[CH3:18])[NH:7][C:6]=2[CH:8]=1

Participants

3

Reactant 2

HCID 5209072-Butanamine, 3,3-dimethyl-HCID 211978252H-1,2,4-Benzothiadiazine, 3,6-dichloro-, 1,1-dioxide

Product 1

HCID 178463651HCID 178463651, compound

Procedure

Starting from 3,6-dichloro-4H-1,2,4-benzothiadiazine 1,1-dioxide (500 mg; 1.99 mmol) and 1,2,2-trimethylpropylamine (500 mg; 5.62 mmol) with the use of same procedure as in example 21 250 mg (39.8%) of the title compound was prepared; m.p. >220° C.; 1H-NMR (DMSO-d6) ppm; 10.3 (s, 1H, NH), 7.70 (d, 1H, H-8), 7.31 (dd, 1H, H-7), 7.25 (br d, 1H, H-5), 7.15 (br, 1H, NH), 3.75 (q, 1H, CH), 1.10 (d, 3H, CH3), 0.9 (s, 9H, 3×CH3). Analysis: C13H18ClN3O2S requires C, 49.44; H, 5.74; N, 13.3; (found C, 49.37; H, 6.04; N, 13.11).

Sources & evidence

ORD record
ord-b860153b131d4c07901b0651bee8be77
Source dataset
uspto-grants-2001_06
Patent number
US06242443B1

Reaction notes

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