Hydrochloric Acid → HCID 178456973, compound

Participants

Reaction Steps

To a stirred suspension of 7-chloro-3-isopropylamino-5-nitro-4H-1,2,4-benzothiadiazine 1,1-dioxide (200 mg; 0.63 mmol) and zink (200 mg; 3.06 mmol) in acetic acid (20 ml) was added 36% hydrochloric acid (0.3 ml). The mixture was stirred for 12 hr. After filtration and concentation in vacuo the crude product was purified by column chromatography eluting with ethyl acetate:ethanol (9:1). Concentration of the appropriate fractions produced 90 mg of the title compound; m.p. >230° C.

Provenance & Evidence