2-Amino-6-methylheptane → HCID 178443606, compound

HRID 1066118Notes

Reaction equation

HRID 1066118 reaction equation
Cl[C:2]1[NH:7][C:6]2[CH:8]=[CH:9][C:10]([Cl:12])=[CH:11][C:5]=2[S:4](=[O:14])(=[O:13])[N:3]=1.[CH3:15][CH:16]([NH2:23])[CH2:17][CH2:18][CH2:19][CH:20]([CH3:22])[CH3:21]>>[Cl:12][C:10]1[CH:9]=[CH:8][C:6]2[NH:7][C:2]([NH:23][CH:16]([CH3:15])[CH2:17][CH2:18][CH2:19][CH:20]([CH3:22])[CH3:21])=[N:3][S:4](=[O:14])(=[O:13])[C:5]=2[CH:11]=1

Participants

3

Reactant 2

HCID 109822-Amino-6-methylheptaneHCID 127001053,7-dichloro-2H-1,2,4-benzothiadiazine 1,1-dioxide

Product 1

HCID 178443606HCID 178443606, compound

Procedure

Starting from 3,7-dichloro-4H-1,2,4-benzothiadiazine 1,1-dioxide (300 mg; 1.19 mmol) and 1,5-dimethylhexylamine (1 g; 7.73 mmol) and with the use of same procedure as in example 21 260 mg (63.5%) of the title compound was prepared; m.p. >220° C.; 1H-NMR (DMSO-d6) ppm; 10.50 (s, 1H, NH), 7.68 (d, 1H, H-8), 7.63 (dd, 1H, H-5), 7.25 (d, 1H, H-7), 7.1 (br, 1H, NH), 3.85 (q, 1H, CH), 1.5 (m, 4H ), 1.35 (m, 3H ), 1.15 (d, 3H, CH3), 0.85 (d, 6H, 2×CH3).

Sources & evidence

ORD record
ord-2db97c17cfad4ba4bbc6cc00c3a95b23
Source dataset
uspto-grants-2001_06
Patent number
US06242443B1

Reaction notes

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