tert-Butyl isothiocyanate → HCID 178448904, compound

Participants

Reaction Conditions

Reaction Steps

The title compound was prepared from 2-amino-4-chlorobenzenesulfonamide and tert-butyl isothiocyanate by a method analogous to the one described in Example 4 except that the mixture was heated at 60° C. for 6 days. The intermediate N-(2-amino-4-chlorobenzenesulfonyl)-N′-tert-butylthiourea and the ring closed product were both purified by column chromatography; m.p. 291-294° C. (light petroleum/ethyl acetate); 1H-NMR (DMSO-d6): δ 1.39 (s, 9H, C(CH3)3), 6.92 (br s, 1H, NH), 7.17 (d, 1H, ArH), 7.28 (dd, 1H, ArH), 7.68 (d, 1H, ArH), 10.25 (br.s, 1H, NH); MS: m/e 287/289 (M+).

Provenance & Evidence