Ammonia → 2-Amino-5-nitrobenzenesulfonamide

Participants

Reaction Conditions

Reaction Steps

A suspension of 2-chloro-5-nitrobenzenesulfonamide (8 g) in concentrated aqueous ammonia (80 mL) was saturated with ammonia just before its introduction into a sealed vessel. The former was placed in an autoclave and heated at 120° C. for 5 h. The reaction mixture was then concentrated to the half volume by evaporation under reduced pressure and the resulting precipitate was collected by filtration, washed with water and dried to give the title compound (yield: 6.1 g); m.p. 202-204° C.

Provenance & Evidence