Ethyl isothiocyanate → HCID 178463652, compound

HRID 1066167Notes

Reaction equation

HRID 1066167 reaction equation
NC1C=C(F)C(F)=CC=1S(N)(=O)=O.C(N=C=S)C.[NH2:19][C:20]1[CH:25]=[C:24]([F:26])[C:23]([F:27])=[CH:22][C:21]=1[S:28]([NH:31][C:32]([NH:34][CH2:35][CH3:36])=S)(=[O:30])=[O:29]>>[CH2:35]([NH:34][C:32]1[NH:19][C:20]2[CH:25]=[C:24]([F:26])[C:23]([F:27])=[CH:22][C:21]=2[S:28](=[O:30])(=[O:29])[N:31]=1)[CH3:36]

Participants

4

Reactant 3

HCID 10966Ethyl isothiocyanateHCID 11150584HCID 11150584, compoundHCID 153708581993-10-8

Product 1

HCID 178463652HCID 178463652, compound

Procedure

Starting from 2-amino-4,5-difluorobenzenesulfonamide and ethyl isothiocyanate, and following a procedure analogous to the one described in Example 4a, N-(2-amino-4,5-difluorobenzenesulfonyl)-N′-ethylthiourea was prepared. The crude compound was used without further purification in a cyclisation step analogous to the one described in Example 4b to give the title compound; m.p. 246-252° C.

Workup

  1. customwas prepared
  2. customThe crude compound was used without further purification in a cyclisation step analogous to the one

Sources & evidence

ORD record
ord-43454043d33a4560b6a2e77c8c7c5ce5
Source dataset
uspto-grants-2001_06
Patent number
US06242443B1

Reaction notes

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