反应详情

温度

50 °C

A mixture of formic acid (1 mL) and acetic anhydride (2 mL) was heated at 50° C. for 20 min. After cooling at room temperature, 3-(2-aminoethyl)amino-7-chloro-4H-1,2,4-benzothiadiazine 1,1-dioxide monohydrate (0.5 g) was added, and the reaction mixture was stirred for 2 h, then supplemented with water (20 mL) and stirred for 20 min. The precipitate was collected by filtration, washed with water and dried (yield: 0.3 g); m.p. 245-247° C.

1. temperatureAfter cooling at room temperature
2. stirringstirred for 20 min
3. filtrationThe precipitate was collected by filtration
4. washwashed with water
5. customdried (yield: 0.3 g)