Formic Acid → HCID 178523417, compound

HRID 1066170Notes

Reaction equation

HRID 1066170 reaction equation
[CH:1]([OH:3])=O.C(OC(=O)C)(=O)C.O.[NH2:12][CH2:13][CH2:14][NH:15][C:16]1[NH:21][C:20]2[CH:22]=[CH:23][C:24]([Cl:26])=[CH:25][C:19]=2[S:18](=[O:28])(=[O:27])[N:17]=1>O>[Cl:26][C:24]1[CH:23]=[CH:22][C:20]2[NH:21][C:16]([NH:15][CH2:14][CH2:13][NH:12][CH:1]=[O:3])=[N:17][S:18](=[O:28])(=[O:27])[C:19]=2[CH:25]=1

Participants

5

Reactant 3

HCID 284Formic AcidHCID 7918Acetic AnhydrideHCID 178511337HCID 178511337, compound

Product 1

HCID 178523417HCID 178523417, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
50 °C

Procedure

A mixture of formic acid (1 mL) and acetic anhydride (2 mL) was heated at 50° C. for 20 min. After cooling at room temperature, 3-(2-aminoethyl)amino-7-chloro-4H-1,2,4-benzothiadiazine 1,1-dioxide monohydrate (0.5 g) was added, and the reaction mixture was stirred for 2 h, then supplemented with water (20 mL) and stirred for 20 min. The precipitate was collected by filtration, washed with water and dried (yield: 0.3 g); m.p. 245-247° C.

Workup

  1. temperatureAfter cooling at room temperature
  2. stirringstirred for 20 min
  3. filtrationThe precipitate was collected by filtration
  4. washwashed with water
  5. customdried (yield: 0.3 g)

Sources & evidence

ORD record
ord-100ba8fdbd3240baabbb86904e5d23cf
Source dataset
uspto-grants-2001_06
Patent number
US06242443B1

Reaction notes

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