1-Adamantaneacetyl chloride → HCID 20660039, compound

HRID 1066247Notes

Reaction equation

HRID 1066247 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[N:9]([CH2:13][C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH:8]=[CH:7]2)([O-])=O.[C:21]12([CH2:31][C:32](Cl)=[O:33])[CH2:30][CH:25]3[CH2:26][CH:27]([CH2:29][CH:23]([CH2:24]3)[CH2:22]1)[CH2:28]2>>[O:33]=[C:32]([NH:1][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[N:9]([CH2:13][C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH:8]=[CH:7]2)[CH2:31][C:21]12[CH2:30][CH:25]3[CH2:26][CH:27]([CH2:29][CH:23]([CH2:24]3)[CH2:22]1)[CH2:28]2

Participants

3

Reactant 2

HCID 27718821-Adamantaneacetyl chlorideHCID 57163070HCID 57163070, compound

Product 1

HCID 20660039HCID 20660039, compoundYield 60.4%

Procedure

Prepared according to the method of Example 15b) from 5-nitro-1H-indole-1-acetic acid, 1,1-dimethylethyl ester (0.29 g) and 1-adamantaneacetyl chloride (0.20 g) to give the title compound as a white solid (0.24 g).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-250cbfa2136f4960a9dfcf4e7f8d28f2
Source dataset
uspto-grants-2001_06
Patent number
US06242470B1

Reaction notes

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