Hydrofluoric Acid → HCID 70146110, compound

Participants

Reaction Steps

The compound (12-11) (0.93 g) was hydrolyzed in acetonitrile (30 ml) with 46% hydrofluoric acid (1.55 ml). The crude product obtained by the conventional treatment was purified by silica gel chromatography (n-hexane/ethyl acetate=7/3-1/1), and the compound obtained was further fractionated by HPLC to give isopropyl 9-{2(R)-4,4-difluoro-3(R)-hydroxydecyl]-3(R)-hydroxy-5-oxocyclopentyl}nonanoate (12-12).

Provenance & Evidence