HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methyl-1,2,3,6-tetrahydropyridin-1-ium-5-carboxylic acid;chloride → 1-methylpiperidine-3-carboxylic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methyl-1,2,3,6-tetrahydropyridin-1-ium-5-carboxylic acid;chloride | HCID 22368 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-methylpiperidine-3-carboxylic Acid | HCID 2736937 | 92% |
Reaction Steps
Arecaidine hydrochloride (4 grams) (22.6 mmoles) was hydrogenated in water (100 ml) using 10% Pd—C at 40 psi at 25° C. for 24 hours. The catalyst was filtered off and washed with water. The aqueous solution was shaken with BioRad AG1X8 resin (OH− form) (23 ml bed) and after 5 minutes the resin was filtered off and washed with water. The aqueous solution was evaporated to give the title compound (Yield: 2.95 grams, 92%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06242458B1 |
| Source dataset | uspto-grants-2001_06 |
| ORD ID | ord-8f7e8acc9a3f409ba8d43cc8258b01a3 |
| Source note | uspto-grants-2001_06 |