3-Pyridineacetic acid → 3-Piperidineacetic acid

HRID 1066313Notes

Reaction equation

HRID 1066313 reaction equation
Cl.[N:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH2:8][C:9]([OH:11])=[O:10])[CH:3]=1.N1C=CC=C(CC(O)=O)C=1>>[NH:2]1[CH2:7][CH2:6][CH2:5][CH:4]([CH2:8][C:9]([OH:11])=[O:10])[CH2:3]1

Participants

3

Reactant 2

HCID 1083-Pyridineacetic acidHCID 27237243-Pyridineacetic acid, hydrochloride (1:1)

Product 1

HCID 2836963-Piperidineacetic acidYield 80.5%

Procedure

3-Pyridylacetic acid hydrochloride (13 grams) (74.9 mmoles) was hydrogenated as described in Preparative Example 15 to give a mixture of unreacted 3-pyridylacetic acid and the title compound (76:24) (8.63 grams, MH+ 144).

Workup

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Sources & evidence

ORD record
ord-26cc61a7c8cc4da984dd8bf08704520a
Source dataset
uspto-grants-2001_06
Patent number
US06242458B1

Reaction notes

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