反应详情

温度

47.5 °C

The above partially purified product of N-(n-pentanesulfonyl)-3-(acetylamino)-4-nitrobenzamide was mixed with 300 ml of water and 500 ml of ethanol. Two-hundred grams of a 10%-sodium hydroxide aqueous solution were added thereto, and the mixture was stirred at 45 to 50° C. for 6 hours. The solvent (approx. 300 ml) was evaporated under reduced pressure. The resulting residue was neutralized with 10% hydrochloric acid aqueous solution and adjusted to pH 2 with diluted hydrochloric acid. The precipitated crystals were collected by filtration and dried to give 85.0 g of yellow crystals of N-(n-pentanesulfonyl)-3-amino-4-nitrobenzamide.

1. customThe solvent (approx. 300 ml) was evaporated under reduced pressure
2. filtrationThe precipitated crystals were collected by filtration
3. customdried