2,4-Dimethylpyridine → HCID 22388276, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-phenylbenzaldehyde (6.45 g), 2,4-lutidine (7.59 g), and acetic anhydride (10 ml) was heated in a bath at 150° C. for 12 hours and then heated under reflux for 12 hours. The reaction mixture was concentrated to dryness under reduced pressure, and the resulting residue was purified by silica-gel column chromatography (eluent, hexane:ethyl acetate=9:1 to 5:1) to give 4.35 g of yellow solid material of (E)-4-methyl-2-(4-phenylphenyl)ethenylpyridine.

Provenance & Evidence