HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Hydroxide → 5-bromo-2-methoxybenzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | 5-Bromo-2-methoxybenzene-1-sulfonyl chloride | HCID 520020 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 5-bromo-2-methoxybenzenesulfonamide | HCID 8317967 | — |
Reaction Steps
To 5-bromo-2-methoxybenzenesulfonyl chloride (45g; 157.6 mmol, from Lancaster Chemical) at 0° C. in THF, was added concentrated NH4OH (42.5 mL) and the reaction mixture was brought to r.t. for 2 h. The reaction mixture was diluted with EtOAc, extracted with NaHCO3 (2×), brine, and the organic phase was dried over MgSO4. The solvent was removed to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06242493B1 |
| Source dataset | uspto-grants-2001_06 |
| ORD ID | ord-d088f16016da428485a0eb1a1e3a4582 |
| Source note | uspto-grants-2001_06 |