HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → HCID 131722609, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Trifluoromethanesulfonate | HCID 2758875 | — |
| Reactant | HCID 16724944 | HCID 16724944 | — |
| Reactant | HCID 21198699 | HCID 21198699 | — |
| Reactant | 6-Fluoronaphthalen-2-ol | HCID 21198711 | — |
| Catalyst | Ferrocene-1,1'-bis-(diphenylphosphine) | HCID 635956 | — |
| Catalyst | (1E,4E)-1,5-diphenylpenta-1,4-dien-3-one; palladium | HCID 6505921 | — |
| Product | HCID 131722609 | HCID 131722609 | 47% |
Reaction Steps
The naphthol of Step 3 was converted to the triflate with triflic anhydride/pyridine in CH2Cl2 at 0° C. This was coupled with the organozinc of the benzyl bromide of step 2 in example 13, with dppf and Pd(dba)2. This yielded the title compound in 47% yield after purification by silica gel chromatography (10% EtOAc in hexane).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06242493B1 |
| Source dataset | uspto-grants-2001_06 |
| ORD ID | ord-0a04904e98314476a7fb1f2be3e554d6 |
| Source note | uspto-grants-2001_06 |