Ethyl 3-phenylprop-2-enoate → ethyl (2E)-3-(5-fluoro-2-methylphenyl)prop-2-enoate

HRID 1066368Notes

Reaction equation

HRID 1066368 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:10])=[C:6]([CH:9]=1)[CH:7]=O.[C:11]([O:21][CH2:22][CH3:23])(=[O:20])[CH:12]=CC1C=CC=CC=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:10])=[C:6](/[CH:7]=[CH:12]/[C:11]([O:21][CH2:22][CH3:23])=[O:20])[CH:9]=1

Participants

3

Reactant 2

HCID 7649Ethyl 3-phenylprop-2-enoateHCID 27590125-Fluoro-2-methylbenzaldehyde

Product 1

HCID 131722610ethyl (2E)-3-(5-fluoro-2-methylphenyl)prop-2-enoate

Procedure

5-Fluoro-2-methylbenzaldehyde (40.58 g; 294 mmol) was converted to the ethyl cinnamate according to step 1 of example 1 to yield 40.81 g. of the title compound.

Workup

  1. customto yield 40.81 g

Sources & evidence

ORD record
ord-f894d52001624444b21539639d2bc9af
Source dataset
uspto-grants-2001_06
Patent number
US06242493B1

Reaction notes

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