5-Benzyloxyindole → HCID 131722611, compound

HRID 1066369Notes

Reaction equation

HRID 1066369 reaction equation
Br[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([F:9])=[CH:5][C:4]=1/[CH:10]=[CH:11]/[C:12]([O:14][CH2:15][CH3:16])=[O:13].[C:17]1([CH2:23][O:24][C:25]2[CH:26]=[C:27]3[C:31](=[CH:32][CH:33]=2)[NH:30][CH:29]=[CH:28]3)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[C:17]1([CH2:23][O:24][C:25]2[CH:26]=[C:27]3[C:31](=[CH:32][CH:33]=2)[NH:30][C:29]([CH2:2][C:3]2[CH:8]=[CH:7][C:6]([F:9])=[CH:5][C:4]=2/[CH:10]=[CH:11]/[C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:28]3)[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 146245-BenzyloxyindoleHCID 131722612HCID 131722612, compound

Product 1

HCID 131722611HCID 131722611, compound

Procedure

The benzylic bromide of Step 2 (3.16 g; 11.0 mmol) was coupled with 5-(phenylmethoxy)indole according to the same procedure described in step 1 of example 2 to yield 2.27 g of the title compound.

Sources & evidence

ORD record
ord-43fc008b82204b41a1fddcf93e5413c2
Source dataset
uspto-grants-2001_06
Patent number
US06242493B1

Reaction notes

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