5-bromo-2-methoxybenzenesulfonamide → HCID 21198701, compound

HRID 1066371Notes

Reaction equation

HRID 1066371 reaction equation
[Na].[Br:2][C:3]1[CH:4]=[CH:5][C:6]([O:41][CH3:42])=[C:7]([S:9]([NH:12][C:13](=[O:40])/[CH:14]=[CH:15]/[C:16]2[CH:21]=[C:20]([F:22])[CH:19]=[CH:18][C:17]=2[CH2:23][C:24]2[CH:25]=[C:26]3[C:30](=[CH:31][CH:32]=2)[N:29]([CH2:33][C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[CH:28]=[CH:27]3)(=[O:11])=[O:10])[CH:8]=1.BrC1C=CC(OC)=C(S(N)(=O)=O)C=1>>[Br:2][C:3]1[CH:4]=[CH:5][C:6]([O:41][CH3:42])=[C:7]([S:9]([NH:12][C:13](=[O:40])/[CH:14]=[CH:15]/[C:16]2[CH:21]=[C:20]([F:22])[CH:19]=[CH:18][C:17]=2[CH2:23][C:24]2[CH:25]=[C:26]3[C:30](=[CH:31][CH:32]=2)[N:29]([CH2:33][C:34]2[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=2)[CH:28]=[CH:27]3)(=[O:10])=[O:11])[CH:8]=1

Participants

3

Reactant 2

HCID 83179675-bromo-2-methoxybenzenesulfonamideHCID 131722615HCID 131722615, compound

Product 1

HCID 21198701HCID 21198701, compoundYield 41.3%

Procedure

The acid of Step 3 (219 mg; 0.57 mmol) was coupled with 5-bromo-2-methoxybenzenesulfonamide of example 10, step 5 according to step 5 of example 1 to yield 149 mg of the title compound.

Sources & evidence

ORD record
ord-2086cf56312040b988afd9fe025e6add
Source dataset
uspto-grants-2001_06
Patent number
US06242493B1

Reaction notes

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