2,4-Dimethylthiazole-5-sulfonamide → HCID 70229570, compound

HRID 1066374Notes

Reaction equation

HRID 1066374 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([CH2:11][C:12]1[C:13](/[CH:18]=[CH:19]/[C:20]([OH:22])=O)=[N:14][CH:15]=[CH:16][CH:17]=1)=[CH:5]2.[CH3:23][C:24]1[S:25][C:26]([S:30]([NH2:33])(=[O:32])=[O:31])=[C:27]([CH3:29])[N:28]=1>>[CH3:23][C:24]1[S:25][C:26]([S:30]([NH:33][C:20](=[O:22])/[CH:19]=[CH:18]/[C:13]2[C:12]([CH2:11][C:6]3[NH:7][C:8]4[C:4]([CH:5]=3)=[CH:3][C:2]([Cl:1])=[CH:10][CH:9]=4)=[CH:17][CH:16]=[CH:15][N:14]=2)(=[O:31])=[O:32])=[C:27]([CH3:29])[N:28]=1

Participants

3

Reactant 2

HCID 128731882,4-Dimethylthiazole-5-sulfonamideHCID 21198709HCID 21198709, compound

Product 1

HCID 70229570HCID 70229570, compound

Procedure

The acid of Step 4 (283 mg; 0.90 mmol) was coupled with 2,4-dimethyl-1,3-thiazole-5-sulfonamide (from Maybridge Chemical) according to step 5 of example 1 to yield 315 mg of the title compound.

Sources & evidence

ORD record
ord-fd8f2f2be49740ec9e6f11361abac011
Source dataset
uspto-grants-2001_06
Patent number
US06242493B1

Reaction notes

Loading…