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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1066414Generated: November 2, 2026

Chlorotrimethylsilane → N2-Isobutyryl-2'-O-(imidazol-1-yl)butylguanosine

https://huagongshe.com/reaction/1066414

Reaction equation

Participants

RoleNameHCIDCharge
ReactantChlorotrimethylsilaneHCID 6397—
ReactantIsobutyryl chlorideHCID 62325—
Reactant2'-O-(Imidazol-1-yl)butylguanosineHCID 136079785—
SolventPyridineHCID 1049—
ProductN2-Isobutyryl-2'-O-(imidazol-1-yl)butylguanosineHCID 136132482—

Reaction Steps

2′-O-(imidazol-1-yl)butylguanosine in pyridine will be treated with trimethylsilyl chloride (5 eq) and isobutyryl chloride (5 eq) as per the procedure of Example 4 to yield the product.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06242592B1
Source datasetuspto-grants-2001_06
ORD IDord-7e095911b1244835bdfa84d62c25bbaf
Source noteuspto-grants-2001_06