反应详情

4-hydroxybenzyl alcohol (6.2 g, 0.0.05 mol) was dissolved in aqueus sodium hydroxide (5N, 30 mL). Toluene (30 mL) was added followed by 1-(2-chloroethyl)piperidine hydrochloride (9.29 g, 0.05 mol) and benzyltriethylamumonium bromide (0.3 g). The reaction mixture was heated with vigorous stirring for 1.5 h. The layers were separated, the aqueous layer was extracted with toluene (2×15 mL). Combined organic extracts and organic layer was washed with water (50 mL), brine (50 mL), dried over sodium sulfate, and concentrated on a rotary evaporator to give 8.725 g (75%) of alcohol (3a) as a yellowish brown oil.

1. temperatureThe reaction mixture was heated
2. customThe layers were separated
3. extractionthe aqueous layer was extracted with toluene (2×15 mL)
4. washCombined organic extracts and organic layer was washed with water (50 mL), brine (50 mL)
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated on a rotary evaporator