Ethanol → 2-(4-Cyclopropanecarbonyl-phenyl)-2-methylpropionamide

HRID 1066484Notes

Reaction equation

HRID 1066484 reaction equation
[CH:1]1([C:4]([C:6]2[CH:11]=[CH:10][C:9]([C:12]([CH3:16])([CH3:15])[C:13]#[N:14])=[CH:8][CH:7]=2)=[O:5])[CH2:3][CH2:2]1.C([OH:19])C.O>[OH-].[K+]>[CH:1]1([C:4]([C:6]2[CH:7]=[CH:8][C:9]([C:12]([CH3:16])([CH3:15])[C:13]([NH2:14])=[O:19])=[CH:10][CH:11]=2)=[O:5])[CH2:2][CH2:3]1

Participants

5

Reactant 3

HCID 702EthanolHCID 962WaterHCID 234998454-(Cyclopropylcarbonyl)-alpha,alpha-dimethylbenzeneacetonitrile

Product 1

HCID 234998512-(4-Cyclopropanecarbonyl-phenyl)-2-methylpropionamide

Reagents, catalysts & solvents 1

HCID 14797Potassium HydroxideSolvent2×

Procedure

Dissolve 2-(4-cyclopropanecarbonyl-phenyl)-2-methyl-propionitrile (100 mg) in aqueous ethanolic potassium hydroxide (2 mL) (prepared from ethanol (5 mL), water (5 mL) and solid potassium hydroxide (1.5 g). Stir overnight at room temperature, then heat at reflux for 6 hours. Cool and evaporate the solvent in vacuo to give the title compound.

Workup

  1. temperatureheat
  2. temperatureat reflux for 6 hours
  3. temperatureCool
  4. customevaporate the solvent in vacuo

Sources & evidence

ORD record
ord-73ea2ec80d9b4304bd8e31b9c2cbaa21
Source dataset
uspto-grants-2001_06
Patent number
US06242606B1

Reaction notes

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