Ammonia → HCID 86756993, compound

HRID 1066498Notes

Reaction equation

HRID 1066498 reaction equation
[F:1][B-:2]([F:5])([F:4])[F:3].[CH2:6]([O:13][C:14]1[CH:15]=[C:16]([CH:22]=[CH:23][CH:24]=1)[C:17](=[NH:21])OCC)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[NH3:25]>C(O)C>[F:1][B-:2]([F:5])([F:4])[F:3].[CH2:6]([O:13][C:14]1[CH:15]=[C:16]([CH:22]=[CH:23][CH:24]=1)[C:17]([NH2:21])=[NH:25])[C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 21200268HCID 21200268, compound

Product 1

HCID 86756993HCID 86756993, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
-70 °C

Procedure

A suspension of 8.57 g of ethyl m-benzyloxybenzimidate tetrafluoroborate in ethanol (120 ml) was cooled to −70° C. and then treated with liquid ammonia (100 ml). The cooling bath was removed and the reaction mixture stirred for 69 h until the reaction was complete (TLC analysis). The solvent was removed in vacuo to give the desired m-benzyloxybenzamidine tetrafluoroborate as a white solid, mp 125°-127° C., that was essentially pure and used without further purification in the next step.

Workup

  1. customThe cooling bath was removed
  2. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-440d4a9e14e54018944e51464d59731e
Source dataset
uspto-grants-2001_06
Patent number
US06242601B1

Reaction notes

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