Hydrochloric Acid → HCID 178489614, compound

Participants

Reaction Steps

60 mg of 5-methyl-pyridine-2-sulfonic acid [2-(2-allyloxy-pyridin-4-yl)-6-methoxy-5-(2-methoxy-phenoxy)-pyrimidin-4-yl]-amide, product of example 39, were suspended in THF (5 ml), treated at RT with 2.2 mg of tetrakis-(triphenylphosphine)palladium and stirred for 5 minutes after which time 6.4 mg of NaBH4 were added. The mixture was stirred for 2 h until the reaction was completed according to TLC analysis. The reaction mixture was poured into cold diluted HCl, the product extracted into AcOEt. The organic layer was dried over NaSO4 and the solvent removed in vacuo to give 5-methyl-pyridine-2-sulfonic acid [2-(2-hydroxy-pyridin-4-yl)-6-methoxy-5-(2-methoxy-phenoxy)-pyrimidin-4-yl]-amide as a light yellow solid. ISN mass spectrum, m/e 494.1 (M−1 calculated for C23H21N5O6S: 494).

Provenance & Evidence