HRID1066525

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2ccnc(C(=O)O)c2)nc1OC

HCID9892985

未命名化合物

2 次

HCID11229529

1-Chloroethyl Cyclohexyl Carbonate

C9H15ClO3

PRODUCTS

生成物

结构：COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2ccnc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2)nc1OC

HCID54399399

未命名化合物

PROCEDURE

实验过程

In analogy to example 77, from 4-[4-methoxy-5-(2-methoxy-phenoxy)-6-(5-methyl-pyridine-2-sulfonylamino)-pyrimidin-2-yl]-pyridine-2-carboxylic acid, product of example 21, and cyclohexyl 1-chlorethyl carbonate (synthesis described by A. Riondel et al., Tetrahedron, 1988, Vol. 44, 1619) there was obtained 4-[4-methoxy-5-(2-methoxy-phenoxy)-6-(5-methyl-pyridine-2-sulfonylamino)-pyrimidin-2-yl]-pyridine-2-carboxylic acid 1-cyclohexyloxycarbonyloxy-ethyl ester as a white solid. ISN mass spectrum, m/e 692.1 (M−1 calculated for C33H35N5O10S: 692).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a0bf915339e2443c824931d35bba15b4
来源数据集: uspto-grants-2001_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06242601B1
来源说明: uspto-grants-2001_06

反应 SMILES

[CH3:1][O:2][C:3]1[C:8]([O:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[O:16][CH3:17])=[C:7]([NH:18][S:19]([C:22]2[CH:27]=[CH:26][C:25]([CH3:28])=[CH:24][N:23]=2)(=[O:21])=[O:20])[N:6]=[C:5]([C:29]2[CH:34]=[CH:33][N:32]=[C:31]([C:35]([OH:37])=[O:36])[CH:30]=2)[N:4]=1.[C:38](=[O:50])([O:46][CH:47](Cl)[CH3:48])[O:39][CH:40]1[CH2:45][CH2:44][CH2:43][CH2:42][CH2:41]1>>[CH:40]1([O:39][C:38]([O:46][CH:47]([O:36][C:35]([C:31]2[CH:30]=[C:29]([C:5]3[N:4]=[C:3]([O:2][CH3:1])[C:8]([O:9][C:10]4[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=4[O:16][CH3:17])=[C:7]([NH:18][S:19]([C:22]4[CH:27]=[CH:26][C:25]([CH3:28])=[CH:24][N:23]=4)(=[O:21])=[O:20])[N:6]=3)[CH:34]=[CH:33][N:32]=2)=[O:37])[CH3:48])=[O:50])[CH2:45][CH2:44][CH2:43][CH2:42][CH2:41]1