HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Peroxide → (S)-(+)-5-Hydroxy-2-(2-methylbutyloxy)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Peroxide | HCID 784 | — |
| Reactant | (S)-(+)-3-Cyano-4-(2-methylbutyloxy)phenylbenzoic acid | HCID 70230180 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (S)-(+)-5-Hydroxy-2-(2-methylbutyloxy)benzonitrile | HCID 54230638 | — |
Reaction Steps
A mixture of compound 47 (3.00 g, 0.014 mol), hydrogen peroxide (30%, w/v, 150 ml) and THF (200 ml) was heated under reflux for 3 h. The water/THF mixture was removed in vacuo and the oily residue was dissolved in diethyl ether and washed with water. The ether was dried (MgSO4) and evaporated in vacuo to give a viscous, fawn oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06242636B1 |
| Source dataset | uspto-grants-2001_06 |
| ORD ID | ord-9a08940a12bd46279d704702e72eceb7 |
| Source note | uspto-grants-2001_06 |