Succinic anhydride → HCID 70068098, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of (S)-(3-methoxycarbonylmethyl-2-oxopiperazin-1-yl)acetic acid methyl ester (3.67 g) and succinic anhydride (1.5 g) in dimethylformamide (25 ml) was added 4-dimethylaminopyridine (0.2 g) and the solution was stirred for 3 hours at 60° C. The reaction mixture was concentrated under reduced pressure and the concentrate was purified by means of CHP-20 column chromatography (H2O→50% acetonitrile aqueous solution) to give the titled compound (3.44 g) as a colorless oily substance.

Provenance & Evidence