Succinic anhydride → HCID 70230303, compound

Participants

Reaction Steps

A mixture of (S)-(3-methoxycarbonylmethyl-2-oxo-piperazin-1-yl)acetic acid tert-butyl ester (1.0 g) and succinic anhydride (0.7 g) in dimethylformamide (15 ml) was stirred for 5 hours at room temperature. The reaction mixture was concentrated under reduced pressure. The concentrate was dissolved in water (10 ml) and purified by means of CHP-20 column chromatography (H2O→30% acetonitrile aqueous solution) to give the titled compound (1.3 g) as a colorless oily product.

Provenance & Evidence